K Heran Darwin is at New York University Grossman School of Medicine and a regular columnist for EMBO reports.

A machine-learning method predicts whether a genetic variant is pathogenic and affects certain human tissues. The ...

MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...

It is boomtime for metabolism and metabolomics research. One hundred years after Otto Warburg put metabolism at the core of ...

Changing nutrient environments challenge cells as they affect both protein biosynthesis and cell cycle length. This work ...

Human papillomavirus (HPV) and hyperactivated YAP1 form a YAP1-HPV oncogenic alliance to drive the malignant transformation ...

FAO is catalyzed by the mitochondrial trifunctional protein (MTP) and, if overloaded, generates ROS. ROS are boosted during ...

Co-expressing NPY and its inhibitory receptor Y2 in excitatory hippocampal cells allows inhibitory autoregulation of ...

CaMKII activates the HRI/eIF2α signaling pathway and inhibits the proteotoxicity induced by proteasome inhibition through ...

The gut microbiota and its functional metabolites play crucial roles in the development of intestinal fibrosis in patients ...

Metabolic rewiring is essential for osteoclast differentiation and bone resorption. This study shows that glutaminolysis ...